Author

B. K. L. Sim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Chakravarty· 3 shared S. L. Hoffman· 3 shared N. KC· 2 shared A. A. Berry· 1 shared A. Eappen· 1 shared A. Ethala· 1 shared A. H. Idris· 1 shared A. K. Wheatley· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

S. Chakravarty

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence

E. Inbar, A. Eappen, R. T. Alford, W. Reid, R. A. Harrell, M. Hosseini, S. Chakravarty, T. Li, B. K. L. Sim, P. F. Billingsley, S. L. Hoffman

This study shows that knocking out LRIM1 in Anopheles stephensi mosquitoes disrupts microbiome balance, reduces vector competence, and affects reproductive traits.

bioRxiv · Jul 2, 2021Microbiology

Mapping of safe and early chemo-attenuated live Plasmodium falciparum immunization identifies immune signature of vaccine efficacy

S. Borrmann, Z. Sulyok, K. Mueller, R. Fendel, C. Lamsfus Calle, M. Sulyok, J. Friesen, A. Lalremruata, T. L. Sandri, T. T. Nguyen, A. Knoblich, S. Sefried, J. Ibanez, F.-R. Lorenz, H. L. Heimann, , B. Mordmueller

This study evaluates the safety and efficacy of chemo-attenuated Plasmodium falciparum immunization, identifying immune signatures that correlate with vaccine protection.

bioRxiv · Sep 14, 2020Immunology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology