Author

L. Xi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 3 Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

J. Wang· 2 shared Z. Zhang· 2 shared A. A. Berry· 1 shared A. Casimiro-Garcia· 1 shared A. Chandramohan· 1 shared A. Ethala· 1 shared A. H. Idris· 1 shared A. J. Patel· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersPlant Biology

J. Wang

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8 papers

Recent·Most cited

A high confidence Physcomitrium patens plasmodesmata proteome by iterative scoring and validation reveals diversification of cell wall proteins during evolution

S. Gombos, M. M. Miras, V. Howe, L. Xi, M. Pottier, N. S. K. Jasemi, M. Schladt, J. O. Ejike, U. Neumann, S. Hansch, F. Kutting, Z. Zhang, M. Dickmanns, P. Xu, T. Stefan, , W. Schulze

The paper identifies a high-confidence plasmodesmata proteome in Physcomitrium patens using iterative scoring and validation, revealing evolutionary diversification of cell wall proteins.

bioRxiv · Jun 1, 2022Plant Biology

PEP7 is a ligand for receptor kinase SIRK1 to regulate aquaporins and root growth

J. Wang, L. Xi, X. N. Wu, S. Koenig, L. Rohr, T. Neumann, K. Harter, W. X. Schulze

The paper identifies PEP7 as a ligand for the receptor kinase SIRK1, showing it regulates aquaporins and root growth through phosphorylation and water influx.

bioRxiv · Apr 5, 2022 · PreprintPlant Biology

Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes

J. Wang, A. Casimiro-Garcia, B. G. Johnson, J. Duffen, M. Cain, L. Savary, S. Wang, P. Nambiar, M. Lech, S. Zhao, L. Xi, Y. Zhan, J. Olson, J. A. Stejskal, H. Lin, , K. Dower

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

bioRxiv · Dec 2, 2020 · PreprintPharmacology & Toxicology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology

Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2

D. Yao, F. Lao, Z. Zhang, Y. Liu, J. Cheng, F. Ding, X. Wang, L. Xi, C. Wang, X. Yan, R. Zhang, F. Ouyang, H. Ding, T. Ke

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

bioRxiv · May 25, 2020 · PreprintBioengineering

Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

A. J. Patel, Y.-W. Wan, R. Al-Ouran, J.-P. Revelli, M. F. Cardenas, M. Oneissi, L. Xi, A. Jalali, J. Magnotti, D. M. Muzny, H. Doddapaneni, S. Sebastian, K. A. Heck, J. C. Goodman, S. P. Gopinath, , T. J. Klisch

This study identifies three molecular types of meningiomas that better predict recurrence than WHO grading and links aggressive tumors to loss of DREAM complex repression.

bioRxiv · Sep 10, 2019Cancer Biology

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

S. Ng, Y.-C. Juang, A. Chandramohan, H. Y. K. Kaan, A. Sadruddin, T. Y. Yuen, F. J. Ferrer, X. E. C. Lee, L. Xi, C. W. Johannes, C. J. Brown, S. Kannan, P. G. Aronica, N. Berglund, C. S. Verma, , D. P. Lane

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

bioRxiv · May 21, 2019Biochemistry

The ERA-related GTPase AtERG2 associated with mitochondria 18S RNA is essential for early embryo development in Arabidopsis

P. Cheng, H. Li, L. Yuan, H. Li, L. Xi, J. Zhang, J. Liu, Y. Wang, H. Zhao, H. Zhao, S. Han

This study identifies AtERG2, a mitochondrial GTPase in Arabidopsis, as essential for early embryo development, with mutants showing seed abortion and ROS accumulation.

bioRxiv · Sep 18, 2017Plant Biology