Author

S. L. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:clustering· 2 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. Chakravarty· 5 shared B. K. L. Sim· 3 shared K. L. Sim· 3 shared N. KC· 3 shared A. H. Idris· 2 shared B. Mordmueller· 2 shared H. J. Sutton· 2 shared I. A. Cockburn· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersImmunology

S. Chakravarty

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Clonal evolution and specificity of the human T follicular helper cell response to Plasmodium falciparum circumsporozoite protein

I. Wahl, A. Obraztsova, J. Puchan, R. Hundsdorfer, S. Chakravarty, K. L. Sim, S. L. Hoffman, P. Kremsner, B. Mordmueller, H. Wardemann

This study examines the clonal evolution and TCR specificity of human TFH cells responding to PfCSP during malaria immunization, revealing HLA restrictions and epitope-specific dynamics.

bioRxiv · Sep 10, 2021 · PreprintImmunology

Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence

E. Inbar, A. Eappen, R. T. Alford, W. Reid, R. A. Harrell, M. Hosseini, S. Chakravarty, T. Li, B. K. L. Sim, P. F. Billingsley, S. L. Hoffman

This study shows that knocking out LRIM1 in Anopheles stephensi mosquitoes disrupts microbiome balance, reduces vector competence, and affects reproductive traits.

bioRxiv · Jul 2, 2021Microbiology

Mapping of safe and early chemo-attenuated live Plasmodium falciparum immunization identifies immune signature of vaccine efficacy

S. Borrmann, Z. Sulyok, K. Mueller, R. Fendel, C. Lamsfus Calle, M. Sulyok, J. Friesen, A. Lalremruata, T. L. Sandri, T. T. Nguyen, A. Knoblich, S. Sefried, J. Ibanez, F.-R. Lorenz, H. L. Heimann, , B. Mordmueller

This study evaluates the safety and efficacy of chemo-attenuated Plasmodium falciparum immunization, identifying immune signatures that correlate with vaccine protection.

bioRxiv · Sep 14, 2020Immunology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology

Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages

M. Biddau, S. T. R. Kumar, P. Henrich, L. M. Laine, G. J. Blackburn, A. Chokkathukalam, T. B. Li, K. L. Sim, S. L. Hoffman, M. P. Barrett, G. H. Coombs, G. I. McFadden, D. A. Fidock, S. Muller, L. Sheiner

bioRxiv · May 17, 2020 · PreprintCell Biology

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

H. A. McNamara, A. H. Idris, H. J. Sutton, B. J. Flynn, Y. Cai, K. Wiehe, K. E. Lyke, D. Chatterjee, N. KC, S. Chakravarty, K. L. Sim, S. L. Hoffman, M. Bonsignori, R. A. Seder, I. A. Cockburn

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

bioRxiv · Oct 18, 2019 · PreprintImmunology