Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease
A. CHAKRABORTY, S. G. Sreenivasmurthy, W. Miller, W. Huai, T. Biswas, S. M. Mandal, L. Bosca, B. Krishnan, G. Ghosh, T. Hazra
This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.
bioRxiv · Oct 26, 2023Biochemistry