G. Ghosh

Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

This study identifies dual-specific autophosphorylation in IKK2, showing tyrosine autophosphorylation and ATP-contacting residue K44 regulate substrate specificity for IκBα phosphorylation during NF-κB activation.

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease

This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.

Structural Requirements for Reverse Transcription by a Diversity-generating Retroelement

This study identifies how surrounding RNA structures facilitate reverse transcription in DGRs by positioning an RNA homoduplex for cis-priming and regulating mutagenesis.

Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

This study determines the structure of NF-κB p52 homodimer-DNA complexes and shows how DNA conformation and binding kinetics influence transcriptional activation.

Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly

The paper identifies a mechanism where SR proteins cooperatively bind pre-mRNA to form a scaffold, which is then selectively displaced by excess U1 snRNP to facilitate spliceosome assembly.

Chromogranin A plays a crucial role in the age-related development of insulin resistance and hypertension

This study shows that Chromogranin A deficiency in mice prevents age-related insulin resistance and hypertension, with hypertension reversing spontaneously as mice age.

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

The paper investigates how a three-dimensional pre-mRNA structural scaffold influences spliceosomal component recruitment beyond traditional splice signals.

Discovery of an IKK2 Site that Allosterically Controls Its Activation

This paper identifies a novel allosteric site on IKK2 that can be targeted by small-molecule inhibitors to block its activity without ATP-competitive off-target effects.

The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.

Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing

The paper shows that exonic stem-loops upstream of introns regulate splicing by modulating splicing factor accessibility.