CDKL5 regulates p62-mediated selective autophagy and host antiviral defense
J. W. Thinwa, Z. Zou, E. Parks, S. Sebti, K. Hui, V. Singh, Y. Wei, G. Urquhart, J. L. Jewell, J. K. Pfeiffer, B. Levine, T. A. Reese, M. U. Shiloh
This study identifies CDKL5 as a regulator of virophagy, showing it promotes p62-mediated autophagy of viral capsids and enhances antiviral defense.
bioRxiv · Sep 20, 2022Microbiology