T. Krueger

Patient-derived lymphomoids preserve the tumor architecture and allow to assess response to therapies in lymphoma

This study develops lymphomoids from patient lymphoma samples to assess therapy response, showing consistency with clinical outcomes.

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus.

This study shows that tRNA hypomodification in Aspergillus fumigatus leads to 5-fluorocytosine resistance through premature activation of a cross-pathway control system.

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

Numerical investigation of heterogeneous soft particle pairs in inertial microfluidics

This study investigates how softness differences between particles affect their pairing behavior in microfluidic channels using simulations.

Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma

This study identifies apical annuli in Toxoplasma gondii as specialized sites for post-invasion secretion of dense granules, essential for parasite growth and host cell remodeling.

Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

The paper investigates the endosomal system in Trypanosoma brucei, revealing it as a continuous membrane system rather than distinct compartments, enabling rapid membrane trafficking.

Lattice-Boltzmann Modelling for Inertial Particle Microfluidics Applications -- A Tutorial Review

This paper reviews lattice-Boltzmann methods for simulating inertial particle microfluidics applications, providing a guide and case studies.

Effect of vessel compression on blood flow in microvascular networks: implications for tumour tissue hypoxia

This study numerically examines how vessel compression in microvascular networks affects red blood cell transport, finding reduced average haematocrit and increased heterogeneity.

Numerical study of the formation and stability of a pair of particles of different sizes in inertial microfluidics

This study investigates how particle size and initial positioning affect the formation and stability of pairs in inertial microfluidics.

Red blood cell lingering modulates hematocrit distribution in the microcirculation

This study quantifies how red blood cell lingering at microvascular bifurcations affects hematocrit distribution and shows its correlation with RBC membrane rigidity and bifurcation geometry.

Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome.

This study investigates the role of RNA interference in Aspergillus fumigatus by analyzing genetic variation and functional outcomes of RNAi component knockouts.

Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media

This study models red blood cell dynamics in extravascular tissues as disordered porous media, finding that structural disorder increases apparent viscosity and promotes RBC homogeneity.

Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen

This study identifies HscA as an effector protein from Aspergillus fumigatus that redirects phagosomes to the recycling expulsion pathway by anchoring p11, affecting susceptibility to invasive pulmonary aspergillosis.

Ubiquitous bacterial polyketides induce cross-kingdom microbial interactions

The paper identifies arginine-derived polyketides as bacterial signals that induce natural product production in fungi, revealing cross-kingdom microbial interactions in soil ecosystems.

Vessel compression biases red blood cell partitioning at bifurcations in a haematocrit-dependent manner: implications for tumour blood flow

This study uses a computational model to show vessel compression affects red blood cell partitioning at bifurcations in a haematocrit-dependent way, impacting tumour oxygenation.

Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation

The paper investigates how abnormal vascular morphology affects haematocrit distribution and tissue oxygenation in tumours, introducing a metric λ to monitor anti-angiogenic treatment efficacy.

Biotinylated surfome profiling identifies potential biomarkers for diagnosis and therapy of Aspergillus fumigatus infection

This study identifies 314 surface proteins of Aspergillus fumigatus using biotinylation and LC-MS/MS, proposing them as potential diagnostic and therapeutic targets.

The dynamic surface proteomes of allergenic fungal conidia

This study identifies dynamic surface and secreted proteins of Aspergillus fumigatus conidia under different conditions and compares them to other allergenic molds.

Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

This study identifies antifungal extracellular vesicles (afEVs) released by human neutrophils in response to Aspergillus fumigatus, which associate with fungal cells and reduce growth through antimicrobial cargo.

Tissue- and cellular-level allocation of autotrophic and heterotrophic nutrients in the coral symbiosis -- A NanoSIMS study

This study uses NanoSIMS and TEM to quantify subcellular nutrient allocation in corals under different feeding and temperature conditions, showing how autotrophic and heterotrophic nutrients are distributed and affected by temperature.

A stochastic model of metastatic bottleneck predicts patient outcome and therapy response

The paper develops a stochastic model of metastatic bottleneck to predict patient outcomes and therapy response, showing that interventions targeting the bottleneck are more effective than reducing overall tumor burden.

Ancient symbiosis confers desiccation resistance to stored grain pest beetles

The paper shows ancient bacterial symbionts in beetles enhance desiccation resistance by altering cuticle properties, aiding survival in dry environments.