C. M. Hogaboam

This study shows that the CSD peptide LTI-2355 improves phagocytic and reduces pro-inflammatory activity in myeloid cells from IPF and PASC-F patients.

This study examines the role of LOXL2 in IPF using Simtuzumab, finding it enhances myofibroblast differentiation and fibrosis but shows no therapeutic efficacy.

This study examines the effects of nintedanib and pirfenidone on senescent lung fibroblasts, finding they do not induce apoptosis and may increase fibrotic markers.

This study shows that epithelial plasticity and innate immune activation contribute to lung tissue remodeling after viral infection, protecting against mortality but causing long-term lung dysfunction.

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

The paper uses single-cell RNA sequencing to analyze basal cell diversity in normal and IPF lung, finding increased secretory primed basal cells in IPF and roles for NOTCH2 and NOTCH3 in their regulation.