The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription
K. S. Umphred-Wilson, S. Ratnayake, Q. Tang, R. Wang, B. N. Devaiah, L. Zhou, Q. Chen, D. Meerzaman, D. S. Singer, S. Adoro
This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.
bioRxiv · Jan 29, 2024 · PreprintCancer Biology