Cancer BiologybioRxivPreprint
The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription
K. S. Umphred-Wilson, S. Ratnayake, Q. Tang…·S. Adoro
This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.