Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
V. Kugler, A. Lieb, N. Guerin…·T. Kaserer
DISRUPTOR identifies oncogenic mutations disrupting protein interactions using an Osprey-based protocol, validated on clinically relevant mutations and confirmed experimentally.
S. Wang, S. M. Reeve, A. A. Ojewole…·B. R. Donald
The paper investigates how a mutation in Staphylococcus aureus dihydrofolate reductase affects antifolate resistance and NADPH isomerism through chiral evasion mechanisms.
G. T. Holt, J. D. Jou, N. P. Gill…·B. R. Donald
The paper analyzes energy landscapes of CALP-inhibitor complexes to identify structural and dynamic features contributing to binding efficiency of kCAL01.
S. M. Reeve, D. Si, J. Krucinska…·D. L. Wright
The paper develops novel inhibitors targeting DHFR enzymes in MRSA to overcome trimethoprim resistance, showing low nanomolar activity and human selectivity.
Y. Qi, J. W. Martin, A. W. Barb…·T. G. Oas
The paper introduces a method to visualize and analyze correlated interdomain motions using continuous conformational distributions, applied to study staphylococcal protein A's binding thermodynamics.