Author

V. Kugler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

E. Stefan· 2 shared T. Kaserer· 2 shared A. Feichtner· 1 shared A. Lieb· 1 shared A. Pozza· 1 shared A. Zoumpoulakis· 1 shared B. R. Donald· 1 shared C. A. Fernandes· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

E. Stefan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome.

D. Zuniga, A. Zoumpoulakis, R. F. Veloso, L. Peverini, S. Shi, A. Pozza, V. Kugler, F. Bonnete, T. Bouceba, R. Wagner, P.-J. Corringer, C. A. Fernandes, C. Venien-Bryan

This study investigates two Kir2.1 mutants linked to Andersen-Tawil syndrome, showing they impair channel function through distinct mechanisms, with C154Y causing dominant-negative effects.

bioRxiv · Feb 9, 2024Biophysics

Kinases in motion: impact of protein and small molecule interactions on kinase conformations

V. Kugler, S. Schwaighofer, A. Feichtner, F. Enzler, J. Fleischmann, S. Strich, S. Schwarz, R. Wilson, P. Tschaikner, J. Troppmair, V. Sexl, P. Meier, T. Kaserer, E. Stefan

This study uses KinCon-reporter technology to analyze conformational changes in disease-associated kinases upon drug, regulatory protein, and pathway activation interactions, revealing insights into therapeutic strategies.

bioRxiv · Jan 11, 2024Biochemistry

DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions

V. Kugler, A. Lieb, N. Guerin, B. R. Donald, E. Stefan, T. Kaserer

DISRUPTOR identifies oncogenic mutations disrupting protein interactions using an Osprey-based protocol, validated on clinically relevant mutations and confirmed experimentally.

bioRxiv · Nov 2, 2022 · PreprintCancer Biology