Cancer BiologybioRxivPreprint
ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer
C. Qian, Q. Yang, M. Rotinen…·M. R. Freeman
This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.
DOI 10.1101/2023.09.28.560025