S. You

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

Gut microbiota assemblages of generalist predators are driven by local- and landscape-scale factors

This study examines how environmental factors shape spider gut microbiota composition using high-throughput sequencing, identifying local and landscape-scale drivers.

Altered CD8+ T cell associated aging gene signature in the peripheral blood of patients with Alzheimer's disease.

The paper examines gene expression in CD8+ T cells from Alzheimer's patients and finds altered levels of age-associated genes linked to cognitive decline.

Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation

This study uses comparative modeling and accelerated simulations to reveal how ATP-hydrolysis product release correlates with force generation in the actomyosin complex.

Loss of tristetraprolin activates NF-κB induced phenotypic plasticity and primes transition to lethal prostate cancer

This study shows that loss of ZFP36 promotes NF-κB activation and phenotypic plasticity in prostate cancer, leading to aggressive disease and castration resistance, which can be reversed by NF-κB inhibition.

Contrasting roles of landscape compositions in shaping functional traits of arthropod community in subtropical vegetable fields

The paper evaluates how different habitat compositions affect functional traits of arthropod communities in subtropical vegetable fields, finding that forest and grassland habitats enhance functional diversity while non-brassica plantations and water bodies reduce it.

DNA metabarcoding of gut contents reveals key habitat and seasonal drivers of trophic networks involving generalist predators in agricultural landscapes

This study uses DNA metabarcoding to analyze gut contents of spiders in agricultural landscapes, revealing how environmental factors influence their trophic interactions and diet composition.

Wound-like tumor periphery in human breast cancer predicts a convergent drug nonresponse

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer

This study shows that STK3, typically a tumor suppressor, promotes prostate cancer growth and identifies STK3 inhibitors with therapeutic potential.

Landscape composition mediates suppression of major pests by natural enemies in conventional cruciferous vegetables

This study shows that increasing semi-natural habitats in conventional cruciferous vegetable fields improves pest suppression by natural enemies, with effects varying by pest type and landscape scale.

Lkb1 is a master regulator of VSMC fate and function in mice

This study shows that Lkb1 is essential for maintaining vascular smooth muscle cell (VSMC) identity and function in mice, as its deletion leads to vascular abnormalities and aneurysm formation.

Improved Parameterization of Protein-DNA Interactions for Molecular Dynamics Simulations of PCNA Diffusion on DNA

The paper evaluates protein-DNA interaction parameters in AMBER and CHARMM force fields and proposes optimized Lennard-Jones parameters to better match experimental diffusion coefficients of PCNA on DNA.

RIPK2 Stabilizes c-Myc and is an Actionable Target for Inhibiting Prostate Cancer Metastasis

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

Bionic 3D printed corals

This study develops 3D printed bionic corals that support high-density microalgal growth, mimicking coral structure and function to enhance photosynthesis and bioproduct generation.

Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles

This study identifies distinct palmitoyl-protein signatures in large and small cancer-derived extracellular vesicles using a novel proteomic approach.

Quantitative Proteomic Analysis of Prostate Tissue Specimens Identifies Deregulated ProteinComplexes in Primary Prostate Cancer

This study identifies deregulated protein complexes in prostate cancer tissues using quantitative proteomics and reveals differences between low-grade and high-grade prostate cancer.