Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping
J. J. Credle, M. Robinson, J. Gunn, D. Monaco, B. Sie, A. L. Tchir, J. Hardick, X. Zheng, K. Shaw-Saliba, R. Rothman, S. Eshleman, A. Pekosz, K. Hansen, H. Mostafa, M. Steinegger, H. B. Larman
This paper introduces cRASL-seq, a method for sensitive and high-throughput SARS-CoV-2 detection and genotyping without nucleic acid extraction or reverse transcription.
bioRxiv · Jun 3, 2020Pathology