W. Beatty

Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy's neutralizing antibody problem

This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.

Dual Membrane-Sspanning Anti-Sigma Factors Regulate Vesiculation in Gut Bacteroidota

This study identifies a novel family of Dual Membrane-spanning Anti-sigma factors (Dma) that regulate Outer Membrane Vesicle (OMV) biogenesis in Bacteroides thetaiotaomicron.

Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum

This study identifies multiple pathways for glucose phosphate transport and utilization in Cryptosporidium parvum, revealing alternative mechanisms for obtaining phosphorylated hexose.

Single cell preparations of Mycobacterium tuberculosis damage the mycobacterial envelope and disrupt macrophage interactions

This study shows that common methods to prepare Mycobacterium tuberculosis for experiments damage the bacterial envelope, alter macrophage responses, and affect bacterial survival.

The combined impact of killer whale consumptive and non-consumptive effects on northern sea otter population viability in the Western Aleutians Archipelago, Alaska

Type I IFN signaling mediates NET release to promote Mycobacterium tuberculosis replication and granuloma caseation

This study shows that type I IFN signaling drives NET release in neutrophils, promoting Mtb replication and granuloma caseation.

Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small 1intestinal epithelia

This study shows that ETEC heat-labile toxin causes long-term intestinal damage beyond diarrhea, affecting nutrient absorption and growth in mice.

Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages

This study shows modern A. baumannii clinical isolates replicate inside macrophage vacuoles and escape via lysis, unlike older lab strains.

Encephalitic alphaviruses exploit caveolae-mediated transcytosis at the blood-brain barrier for CNS entry

This study shows alphaviruses use caveolae-mediated transcytosis across the blood-brain barrier to enter the CNS, and IFN restricts this process.