B. S. Moriarity

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study uses indirect CRISPR screening with photoconversion to identify key factors of drug resistance mediated by cell-cell interactions, finding genes that reduce cancer cell apoptosis when knocked out in supporting cells.

This study ablates SYK kinase in primary human NK cells using CRISPR/Cas9, finding it enhances cytotoxicity and cytokine production compared to other gene ablations.

This study identifies early-stage ECM dysregulation in HCM caused by MYH7/MYH6 mutations using hiPSC-derived cardiomyocytes.

This paper describes a non-viral method for efficiently integrating large DNA into primary human T cells using CRISPR-Cas9 and homology-mediated end joining, achieving high functionality and anti-tumor activity.

This study shows that genetic editing of CISH enhances T cell anti-tumor activity independently of PD-L1 expression, outperforming PD-1 and TIGIT disruption in certain contexts.

This paper demonstrates a non-viral method using the Tc Buster transposon system to deliver CAR constructs to primary human NK and T cells, achieving efficient gene expression and functional activity.

This study shows that LynB, a splice variant of Lyn, prevents autoimmunity, while its absence leads to TLR4 hyper-responsiveness and lupus-like disease.

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

The paper compares CBE and ABE base editors for splice-site disruption in T-cells, finding CBEs more reliable and splice-donor targeting most effective.

This paper develops a CRISPR/Cas9-based method to edit human NK cells, enhancing their anti-cancer activity by knocking out ADAM17 and PD1.