B. Wehrle-Haller

This study identifies POU5F1B as a human-specific oncoprotein that enhances cell invasiveness via plasma membrane remodeling through ubiquitination and S-acylation.

This study shows that Akt signaling drives TGF-beta-induced over-secretion of DKK1 and impairs apicobasal polarity in CF airway epithelium, with therapeutic targeting of these pathways restoring polarization.

The paper develops new tools to study how integrin Vβ6 interacts with latent TGFβ1, revealing unique mechanical rearrangements and binding differences with LAP1 and LAP3.

The paper shows kindlin uses membrane diffusion and localization to the integrin nano-layer to activate integrins in focal adhesions, distinct from talin's mechanism.

This study shows that mechanical force increases the ligand promiscuity of αVβ3 integrin by enabling binding to fibronectin through conformational changes.