G. Giannone

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

Actin-Driven Nanotopography Promotes Stable Integrin Adhesion Formation in Developing Tissue

The paper shows that actin-driven membrane protrusions create nanotopographies that enable stable integrin adhesion in Drosophila muscle attachment sites.

Talin and kindlin cooperate to control the density of integrin clusters.

This study shows that talin and kindlin work together to control integrin cluster density, with kindlin enhancing talin and integrin density and facilitating cluster segregation by actomyosin.

Compressive forces stabilise microtubules in living cells

The paper shows that compressive forces stabilize microtubules in living cells through CLASP2 relocation, indicating mechano-responsive properties.

Molecular organization and mechanics of single vimentin filaments revealed by super-resolution imaging

This study uses super-resolution imaging to show vimentin filaments have a 49 nm axial repeat, with subunit unfolding contributing to their extensibility.

The genomic landscape of early stage ovarian high grade serous carcinoma

This study compares genomic features of early and late stage high grade serous ovarian carcinoma, finding no unique mutations or focal copy number alterations but noting differences in ploidy and copy number signatures.

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions

The paper shows kindlin uses membrane diffusion and localization to the integrin nano-layer to activate integrins in focal adhesions, distinct from talin's mechanism.