Degradation of SARS-CoV-2 receptor ACE2 by tobacco carcinogen-induced Skp2 in lung epithelial cells
G.-B. Zhou, G.-Z. Wang, Q. Zhao, F. Liang, C. Zhang, H. Zhang, J. Wang, Z.-Y. Chen, R. Wu, H. Yu, B.-B. Sun, R. Feng, K.-F. Xu
The paper shows tobacco carcinogens increase ACE2 mRNA but reduce ACE2 protein levels via Skp2-mediated ubiquitination, decreasing SARS-CoV-2 infection in lung cells.
bioRxiv · Oct 13, 2020Cell Biology