F. Liang

Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity

This study shows that microinfarcts in mice enhance recurrent stroke severity via NLRP3-dependent trained immunity in microglia.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

Degradation of SARS-CoV-2 receptor ACE2 by tobacco carcinogen-induced Skp2 in lung epithelial cells

The paper shows tobacco carcinogens increase ACE2 mRNA but reduce ACE2 protein levels via Skp2-mediated ubiquitination, decreasing SARS-CoV-2 infection in lung cells.

Rapid detection of SARS-CoV-2 and other respiratory viruses by using LAMP method with Nanopore Flongle workflow

This paper describes a rapid method using LAMP and Nanopore Flongle for detecting SARS-CoV-2 and other respiratory viruses in under two hours.

Aging immune system-related blood cell DNA methylation can predict the onset of early stage colorectal cancer

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death

This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.

The splicing factor U2AF1 contributes to cancer progression through a non-canonical role in translation regulation

This study identifies a non-canonical role of U2AF1 in translation regulation, showing that the S34F mutation enhances interleukin 8 synthesis, promoting cancer progression.