From Structure to Sequence: Identification of polyclonal antibody families using cryoEM
A. Antanasijevic, C. A. Bowman, R. N. Kirchdoerfer, C. A. Cottrell, G. Ozorowski, A. A. Upadhyay, K. M. Cirelli, D. G. Carnathan, C. A. Enemuo, L. M. Sewall, B. Nogal, F. Zhao, B. Groschel, W. R. Schief, D. Sok, , A. B. Ward
This paper uses cryoEM and next-generation sequencing to identify monoclonal antibodies from polyclonal sera and validate their antigen-binding properties.
bioRxiv · Apr 13, 2021 · PreprintImmunology