M. Shin

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

Oxygen carrying nanoemulsions and respiratory hyperoxia eliminate tumor hypoxia-induced suppression and improve cancer immunotherapy

This study shows oxygen-carrying nanoemulsions and respiratory hyperoxia reduce tumor hypoxia, enhance T cell and NK cell infiltration, and improve cancer immunotherapy outcomes.

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

Transcriptomic Profiling Reveals Claudin 18.2 as a Diagnostic Biomarker of Menetrier Disease and the Role of Hedgehog Signaling in Pathogenesis

This study identifies CLDN18.2 as a diagnostic marker for Menetrier Disease and shows that Hedgehog signaling is upregulated and therapeutically targetable in the disease.

SINGLE CELL RESOLUTION OF THE ADULT ZEBRAFISH INTESTINE UNDER CONVENTIONAL CONDITIONS, AND IN RESPONSE TO AN ACUTE VIBRIO CHOLERAE INFECTION.

This study uses single-cell transcriptomics to analyze adult zebrafish intestines under conventional conditions and after Vibrio cholerae infection, revealing immune responses and similarities to mammalian gut.

Relish/NF-kB acts in intestinal stem cells to promote epithelial repair in Drosophila

This study shows that NF-kB in intestinal stem cells is crucial for epithelial repair in Drosophila, as its loss impairs tissue regeneration and increases mortality.

Immune Regulation of Intestinal Stem Cell Proliferation and Differentiation in Drosophila.

This study shows that immune signaling in Drosophila intestinal stem cells is critical for maintaining epithelial homeostasis, with impaired immunity leading to reduced stem cell numbers and defective differentiation.

An integrative process-based model for biomass and yield estimation of hardneck garlic (Allium sativum)

The paper introduces an integrative process-based crop model for garlic to estimate biomass and yield under diverse environmental conditions and assess climate adaptation strategies.

Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine.

This study shows that Lactobacillus brevis affects stem cell division symmetry and tumorigenesis in Drosophila intestine by altering integrin expression and distribution.

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.

High-throughput and all-solution phase African Swine Fever Virus (ASFV) detection using CRISPR-Cas12a and fluorescence based point-of-care system

This paper develops a CRISPR-Cas12a-based system for rapid, sensitive, and specific ASFV detection without nucleic acid amplification, achieving a detection limit of 100 fM.

Complex symbiont-pathogen interactions inhibit intestinal repair

This study shows that Vibrio cholerae inhibits intestinal epithelial repair in Drosophila by interacting with symbiotic bacteria, highlighting the role of the type six secretion system in pathogenesis.

A small single-domain protein folds through the same pathway on- and off- the ribosome

This study shows the src SH3 domain folds through the same pathway whether on or off the ribosome, suggesting the ribosome does not alter its folding mechanism.