K. Marcus

Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria

This paper establishes an immortalised murine desminopathy model and finds reduced mitochondrial proton leak and ADP/ATP translocase levels in desminopathy myotubes.

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein

LUBAC assembles a signaling platform at mitochondria for signal amplification and shuttling of NF-ĸB to the nucleus

This study shows that LUBAC assembles at mitochondria to amplify and shuttle NF-κB signals to the nucleus during TNF activation.

Peroxisomal ATPase ATAD1 acts in quality control of the protein import machinery

The paper investigates the role of ATAD1 in peroxisomal quality control by interacting with PEX5 and influencing its stability.

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

The paper identifies a hydrogen-bonded junction in DNA polymerase clamp loaders that is critical for allosteric communication, preserved across diverse AAA+ ATPases.

Escalating protein supersaturation underlies inclusion formation in muscle proteinopathies

The paper quantifies protein supersaturation in muscle biopsies from PAM patients, showing it escalates near pathological inclusions and correlates with aggregation.

Chemical signatures of honey bee group membership develop via a socially-modulated innate process

This study shows that honey bee nestmate recognition cues develop through age-dependent chemical transitions driven by innate pathways and modulated by social factors, not via a passive homogenization process.