C. A. Franco

Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia

This study shows that defective flow-migration coupling due to ALK1 loss causes arteriovenous malformations in HHT, with integrin-YAP/TAZ signaling as a potential therapeutic target.

Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence

This study identifies organ-specific adhesion molecules critical for Trypanosoma brucei tissue tropism and virulence by showing their role in extravasation and reservoir establishment.

Endothelial cell invasiveness is controlled by myosin IIA-dependent inhibition of Arp2/3 activity

The paper identifies myosin IIA's role in inhibiting Arp2/3 activity to regulate endothelial tip cell protrusions during sprouting angiogenesis.

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling

This paper presents an agent-based model to study how endothelial cells integrate flow and collective cues to preserve vessel bifurcations during angiogenic remodelling, finding that both cues must be balanced for stability.