Author

C. A. Headley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

J. Turner· 4 shared J. B. Torrelles· 3 shared V. Dwivedi· 3 shared A. M. Olmo-Fontanez· 2 shared S. Gautam· 2 shared A. A. Hicks· 1 shared A. A. Schami· 1 shared A. A. Whigham· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

J. Turner

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4 papers

Recent·Most cited

Mitochondrial Transplantation promotes protective effector and memory CD4+ T cell response during Mycobacterium tuberculosis infection and diminishes exhaustion and senescence in elderly CD4+ T cells

C. A. Headley, s. Guatam, A. M. Olmo-Fontanez, A. Garcia-Vilanova, V. Dwivedi, A. A. Schami, S. Weintraub, P. S. Tsao, J. B. Torrelles, J. Turner

This study shows mitochondrial transplantation enhances CD4+ T cell function in elderly individuals and mice infected with Mycobacterium tuberculosis by reducing exhaustion and senescence.

bioRxiv · Jan 24, 2024 · PreprintImmunology

IL-10 receptor blockade delivered simultaneous with BCG vaccination sustains long term protection against Mycobacterium tuberculosis infection in mice

V. Dwivedi, S. Gautam, C. A. Headley, T. Piergallini, J. B. Torrelles, J. Turner

This study shows that combining BCG vaccination with IL-10 receptor blockade in mice provides long-term protection against M.tb infection, improving T cell responses and survival.

bioRxiv · Sep 5, 2021Immunology

Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4+ T Cells in Aging.

C. A. Headley, S. Gautam, A. M. Olmo-Fontanez, A. M. Garcia-Vilanova, V. Dwivedi, A. Akhter, A. Schami, K. Chiem, R. Ault, H. Zhang, H. Cai, A. A. Whigham, J. A. Delgado, A. A. Hicks, P. Tsao, , J. Turner

This study transfers functional mitochondria into aged CD4+ T cells, improving their metabolism, reducing oxidative stress, and enhancing immune function against infections.

bioRxiv · Feb 21, 2021Immunology

Blood RNA Signatures Predict Recent Tuberculosis Exposure in Mice, Macaques and Humans

R. C. Ault, C. A. Headley, A. E. Hare, B. J. Carruthers, A. Mejias, J. Turner

The paper identifies a blood RNA signature that detects recent M.tb exposure in mice, macaques, and humans, with a 6-gene signature showing promise in human cohorts.

bioRxiv · Nov 4, 2019Immunology