Author

C. A. Leduc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Egli· 2 shared D. J. Williams· 2 shared R. L. Leibel· 2 shared B. J. Gonzalez· 1 shared C. A. Doege· 1 shared C. N. Goulbourne· 1 shared D. Zheng· 1 shared G. Stratigopoulos· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

D. Egli

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Author profile →

2 papers

Recent·Most cited

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

B. J. Gonzalez, H. Zhao, J. Niu, D. J. Williams, J. Lee, C. N. Goulbourne, Y. Xing, Y. Wang, J. Oberholzer, X. Chen, C. A. LeDuc, W. K. Chung, H. M. Colecraft, J. Gromada, Y. Shen, , D. Egli

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

bioRxiv · Jan 26, 2021Cell Biology

Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons

L. Wang, Y. Liu, G. Stratigopoulos, S. Panigrahi, L. Sui, C. A. Leduc, H. J. Glover, M. C. De Rosa, L. C. Burnett, D. J. Williams, L. Shang, R. Goland, S. H. Tsang, S. Wardlaw, D. Egli, , R. L. Leibel

This study investigates how BBS mutations affect neuron function and signaling in iPSC-derived neurons, identifying impaired ciliary function and signaling pathways related to energy homeostasis.

bioRxiv · Oct 29, 2020Cell Biology