Author

J. Niu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Plant Biology· 2 Bioengineering· 1 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Research Focus:differential expression· 3 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:plant (other)· 2

Frequent Co-Authors

C. Li· 2 shared Y. Wang· 2 shared A. Pusuluri· 1 shared A. T. Csordas· 1 shared B. J. Gonzalez· 1 shared B. Meng· 1 shared B. Xie· 1 shared B. Xue· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

C. Li

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9 papers

Recent·Most cited

Perinuclear force regulates SUN2 dynamics and distribution on the nuclear envelope for proper nuclear mechanotransduction

J. Niu, X. Wang, W. Zhao, Y. Wang, Y. Qin, X. Huang, B. Xue, C. Li, Y. Sun

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

bioRxiv · Dec 16, 2022 · PreprintCell Biology

Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons

J. Qian, X. Guan, B. Xie, C. Xu, J. Niu, X. Tang, C. Li, H. Colecraft, R. Jaenisch, X. S. Liu

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

bioRxiv · Nov 30, 2022 · PreprintPhysiology

Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites

Y. Han, J. Niu, D. Pan, C. Feng, K. Song, B. Meng, U. Westerlind, Y. Zhang, H. Liu, L. Xu, D. Zhou

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

bioRxiv · Jul 24, 2022 · PreprintImmunology

Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice

X. Yang, Z. Wang, J. Niu, R. Zhai, X. Xue, G. Wu, M. Gong, L. Zhao, C. Zhang

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

bioRxiv · Jun 5, 2022 · PreprintMicrobiology

Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

B. J. Gonzalez, H. Zhao, J. Niu, D. J. Williams, J. Lee, C. N. Goulbourne, Y. Xing, Y. Wang, J. Oberholzer, X. Chen, C. A. LeDuc, W. K. Chung, H. M. Colecraft, J. Gromada, Y. Shen, , D. Egli

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

bioRxiv · Jan 26, 2021Cell Biology

Mutation of IDR1 enhances drought tolerance by reducing ROS production and activating ROS scavenging in rice

X. Zu, Y. Lu, Q. Wang, Y. La, F. Tan, J. Niu, H. Xia, X. Hong, Y. Wu, S. Zhou, K. Li, H. Chen, S. Qiang, Q. Rui, H. Wang, H. La

bioRxiv · Aug 24, 2020 · PreprintPlant Biology

Click-PD: A Quantitative Method for Base-Modified Aptamer Discovery

C. K. L. Gordon, D. T. Wu, T. A. Feagin, A. Pusuluri, A. T. Csordas, M. Eisenstein, C. J. Hawker, J. Niu, H. T. Soh

This paper introduces click-PD, a method for discovering base-modified aptamers with high affinity and specificity using click chemistry and FACS screening.

bioRxiv · May 3, 2019 · PreprintBioengineering

Imaging chromatin interactions at sub-kilobase resolution Via Tn5-FISH

X. Zhang, J. Niu, G. Li, Q. Dai, D. Jin, J. Gao, M. Q. Zhang

This paper introduces Tn5-FISH, a method to visualize chromatin interactions at sub-kilobase resolution and validate results from 3C-derivative methods.

bioRxiv · Apr 7, 2019 · PreprintCell Biology

SmbHLH37 functions antagonistically with SmMYC2 in regulating jasmonate-mediated biosynthesis of phenolic acids in Salvia miltiorrhiza

T. Du, J. Niu, J. Su, S. Li, X. Guo, L. Li, X. Cao, J. Kang

This study identifies SmbHLH37 as an antagonist of SmMYC2 in regulating jasmonate-mediated phenolic acid biosynthesis in Salvia miltiorrhiza.

bioRxiv · Oct 8, 2018Plant Biology