Author

C. A. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

B. Gottgens· 2 shared E. Passegue· 2 shared F. J. Calero-Nieto· 2 shared T. T. Ho· 2 shared X. Wang· 2 shared A. Flohr Svendsen· 1 shared A. Herault· 1 shared A. M. Ellisdon· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

B. Gottgens

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells

P. V. Dellorusso, M. A. Proven, F. J. Calero-Nieto, X. Wang, C. A. Mitchell, F. Hartmann, M. Amouzgar, P. Favaro, A. W. DeVilbiss, J. W. Swann, T. T. Ho, Z. W. Zhao, S. C. Bendall, S. J. Morrison, B. Gottgens, E. Passegue

This study shows autophagy compensates for inflammation-induced metabolic issues in old HSCs, and temporarily boosting autophagy can restore their function.

Cell Stem Cell · Jul 1, 2024Peer-reviewedCell Biology

Stromal inflammation is a targetable driver of hematopoietic aging

E. V. Verovskaya, C. A. Mitchell, F. J. Calero-Nieto, A. Herault, P. D. Dellorusso, X. Wang, S. Y. Zhang, A. Flohr Svendsen, E. M. Pietras, S. T. Bakker, T. T. Ho, B. Gottgens, E. Passegue

This study identifies stromal inflammation as a key driver of hematopoietic aging and shows that blocking IL-1 signaling can improve hematopoietic regeneration.

bioRxiv · Mar 8, 2021 · PreprintCell Biology

Structural analysis of the PTEN:P-Rex2 signalling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1

L. D'Andrea, C. M. Lucato, E. A. Marquez, Y.-G. Chang, S. Civciristov, C. Huang, H. Elmlund, R. B. Schittenhelm, C. A. Mitchell, J. C. Whisstock, M. L. Halls, A. M. Ellisdon

The paper investigates the PTEN:P-Rex2 complex, identifying how cancer mutations disrupt its inhibitory function and hyperactivate Rac1 signaling.

bioRxiv · Apr 11, 2020Biochemistry