S. J. Morrison

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells

This study shows autophagy compensates for inflammation-induced metabolic issues in old HSCs, and temporarily boosting autophagy can restore their function.

Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

An effective sanitizer for fresh produce production: In situ plasma activated water treatment inactivates pathogenic bacteria and maintains the quality of cucurbit fruit

This paper demonstrates that plasma activated water (PAW) effectively reduces pathogenic bacteria on cucurbit fruits while maintaining quality and shelf life, outperforming sodium hypochlorite in some aspects.

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis

This study identifies PHGDH protein expression heterogeneity as a driver of breast cancer metastasis by altering metabolic pathways and promoting dissemination.

Cell size is a determinant of stem cell potential during aging

The paper shows that stem cell enlargement during aging reduces their function, and preventing this enlargement improves function.

Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

The paper develops a new metabolomic method for analyzing rare cell populations, detecting more metabolites in flow-sorted cells and revealing metabolic differences in HSCs and melanoma cells.