BiophysicsbioRxiv
High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Co-receptor CCR5
C. A. Rico, Y. A. Berchiche, M. Horioka…·T. Huber
The paper develops a fluorescence assay to study high-affinity chemokine analogs that show ligand bias at CCR5, finding they bind with subnanomolar affinities and occupy a site not accessible to native chemokines.
DOI 10.1016/j.bpj.2019.07.043