Author

O. Hartley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Furstenberg· 1 shared A. Grahl· 1 shared C. A. Rico· 1 shared C.-J. Tsai· 1 shared E. Lorenzen· 1 shared F. Pamula· 1 shared G. F. X. Schertler· 1 shared H. Gaertner· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. Furstenberg

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2 papers

Recent·Most cited

BiophysicsbioRxivNov 27, 2020

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

P. Isaikina, C.-J. Tsai, N. B. Dietz…·S. Grzesiek

The paper reports the cryo-EM structure of CCR5 bound to a chemokine agonist and Gi protein, revealing its activation mechanism.

DOI 10.1126/sciadv.abg8685

𝕏 PostBluesky

BiophysicsbioRxivMar 16, 2019

High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Co-receptor CCR5

C. A. Rico, Y. A. Berchiche, M. Horioka…·T. Huber

The paper develops a fluorescence assay to study high-affinity chemokine analogs that show ligand bias at CCR5, finding they bind with subnanomolar affinities and occupy a site not accessible to native chemokines.

DOI 10.1016/j.bpj.2019.07.043

humanproteomics

𝕏 PostBluesky