Author

T. Huber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 4 Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Assay:proteomics· 6 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

T. P. Sakmar· 7 shared E. Ceraudo· 3 shared E. Lorenzen· 3 shared M. A. Kazmi· 3 shared H. Tian· 2 shared I. B. Kotliar· 2 shared J. M. Schwenk· 2 shared M. Horioka· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersBiophysics

T. P. Sakmar

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

I. B. Kotliar, E. Ceraudo, K. Kemelmakher-Liben, D. A. Oren, E. Lorenzen, T. Dodig-Crnkovic, M. Horioka-Duplix, T. Huber, J. M. Schwenk, T. P. Sakmar

This study identifies that MRGPRX4 interacts with RAMP2, reducing its signaling and surface expression, and predicts the structure of the MRGPRX4-RAMP2 complex.

bioRxiv · Dec 6, 2022Biochemistry

Entry Pathway for the Inverse Agonist Ligand in the G Protein-Coupled Receptor Rhodopsin

H. Tian, K. M. Gunnison, M. A. Kazmi, T. P. Sakmar, T. Huber

This study investigates the pathway for 11-cis-retinal entry into rhodopsin, finding that it enters through a transmembrane channel between TM5/6, controlled by dynamic allosteric mechanisms.

bioRxiv · May 24, 2021 · PreprintBiophysics

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain.

M. Kowalski-Jahn, H. Schihada, A. Turku, T. Huber, T. P. Sakmar, G. Schulte

The paper develops BRET-based biosensors to study WNT-induced conformational changes in FZD CRD and shows CRD dynamics are not required for WNT/β-catenin signaling.

bioRxiv · May 1, 2021Cell Biology

SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19

S. Pfefferle, T. Guenther, V. Puelles, F. Heinrich, D. Noerz, M. Czech-Sioli, A. Carstens, S. Krasemann, M. Wong, L. Oestereich, T. Magnus, L. Allweiss, C. Edler, A.-S. Schroeder, M. Dandri, , N. Fischer

The paper investigates SARS-CoV-2 infection in carotid arteries of COVID-19 patients using genomic, virologic, histochemical, and transcriptomic analyses, showing productive infection and vascular modulation.

bioRxiv · Oct 10, 2020 · PreprintMicrobiology

Myosin-gelsolin cooperativity in actin filament severing and actomyosin motor activity

V. Vemula, T. Huber, M. Usaj, B. Bugyi, A. Mansson

This study shows that gelsolin and myosin cooperate to enhance actin filament severing through myosin-induced forces and gelsolin's enzymatic activity.

bioRxiv · Sep 2, 2020 · PreprintBiophysics

Uveal Melanoma Oncogene CYSLTR2 Encodes a Constitutively Active GPCR Highly Biased Toward Gq Signaling

E. Ceraudo, M. Horioka, J. M. Mattheisen, T. D. Hitchman, A. R. Moore, M. A. Kazmi, P. Chi, Y. Chen, T. P. Sakmar, T. Huber

bioRxiv · Jun 6, 2019Cancer Biology

Multiplexed Analysis of the Secretin-like GPCR-RAMP Interactome

E. Lorenzen, T. Dodig-Crnkovic, I. B. Kotliar, E. Pin, E. Ceraudo, R. D. Vaughan, M. Uhlen, T. Huber, J. M. Schwenk, T. P. Sakmar

This study identifies GPCR-RAMP interactions using a suspension bead array assay, revealing widespread interactions among secretin-like GPCRs and RAMPs.

bioRxiv · Apr 6, 2019Biochemistry

High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Co-receptor CCR5

C. A. Rico, Y. A. Berchiche, M. Horioka, J. C. Peeler, E. Lorenzen, H. Tian, M. A. Kazmi, A. Furstenberg, H. Gaertner, O. Hartley, T. P. Sakmar, T. Huber

The paper develops a fluorescence assay to study high-affinity chemokine analogs that show ligand bias at CCR5, finding they bind with subnanomolar affinities and occupy a site not accessible to native chemokines.

bioRxiv · Mar 16, 2019Biophysics

DNA-Encircled Lipid Bilayers

K. Iric, M. Subramanian, J. Oertel, N. P. Agarwal, M. Matthies, X. Periole, T. P. Sakmar, T. Huber, K. Fahmy, T.-L. Schmidt

This paper introduces DNA-encircled bilayers (DEBs) as a novel membrane-mimetic system for studying lipid phases and membrane proteins with precise control over size and functionalization.

bioRxiv · Jun 25, 2018Biophysics