Cell BiologybioRxiv
Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice
Y. Wang, K. Shiladardi, T. Hsu…·H. J. Worman
This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.
DOI 10.1073/pnas.2118695119