J.-Y. Shin

The paper shows that torsinA and its activators LAP1 and LULL1 regulate liver triglyceride secretion and steatosis in mice.

This study shows that LAP1-depleted hepatocytes are an ideal system to study nuclear lipid droplets and their response to nutritional changes.

This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.

This study examines a lamin A/C mutation in mice, revealing structural changes in nuclear filaments and chromatin organization linked to striated muscle disease.

This study shows that scaffold-free human mesenchymal stem cell tubes, with specific geometry and morphogen presentation, enhance endochondral bone regeneration in critical-sized femoral defects compared to loose hMSC sheets.

The paper demonstrates that engineered human mesenchymal stem cell condensations with dual BMP-2 and TGF-β1 promote functional healing of critical-sized femoral defects via endochondral ossification, with healing rate and extent dependent on in vivo mechanical environment.