Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
C. Bartolacci, C. Andreani, G. Dias do Vale, S. Berto, M. Melegari, A. C. Crouch, D. L. Baluya, G. Kemble, K. Hodges, J. Starrett, K. Politi, S. L. Starnes, D. Lorenzini, M. G. Raso, L. Solis Soto, , P. P. Scaglioni
This study identifies FASN as a therapeutic target in KRAS-mutant lung cancer by showing its role in lipid metabolism and ferroptosis induction.
bioRxiv · Mar 18, 2021Cancer Biology