B. Gao

Parkinson's Disease-Linked Kir4.2 Mutation R28C Leads to Loss of Ion Channel Function

This study investigates the impact of the Kir4.2R28C mutation on channel function and cellular processes, finding it causes loss of function and disrupts protein stability and trafficking.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants

This study uses deep learning to identify antibodies resistant to SARS-CoV-2 Omicron variants by predicting their binding and escape from mutations.

Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modifications

The paper introduces ELAP-seq, a method to detect pseudouridine modifications in RNA with high sensitivity and resolution, identifying over 10,000 sites in human transcripts.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.

Measuring chondrocyte viability of articular cartilage based on label-free two-photon microscopy and deep learning image analysis

This paper develops a deep learning method to assess chondrocyte viability using label-free two-photon microscopy images from rat and porcine cartilage, achieving 95% accuracy.

Visualization of mitochondrial cristae and mtDNA evolvement and interactions with super-resolution microscopy

This study uses super-resolution microscopy to visualize mitochondrial cristae and mtDNA interactions, revealing their dynamic relationship and distribution patterns under different cellular conditions.

Open-3DSIM: an Open-source three-dimensional structured illumination microscopy reconstruction platform

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis

This study identifies Arabidopsis AAR2 as a conserved splicing factor that also promotes miRNA biogenesis by interacting with HYL1 and regulating its dephosphorylation.

Evolutionary Principles of Bacterial Signaling Capacity and Complexity

This study examines the evolution of bacterial signaling complexity in Campylobacterota, showing increases during niche expansion and decreases during specialization.

A CRISPR-Cas assisted shotgun mutagenesis method for evolutionary genome engineering

This paper introduces CARM, a CRISPR-Cas-based method for whole-genome mutagenesis, and demonstrates its application in evolving yeast strains for increased beta-carotene and S-adenosyl-L-methionine production.

Single cell RNA Sequencing Identifies G-protein Coupled Receptor 87 as a Novel Basal Cell Marker of Distal Honeycomb Cysts in Idiopathic Pulmonary Fibrosis

The paper identifies GPR87 as a novel marker for KRT5+ basal cells in IPF distal bronchioles and honeycomb cysts using single-cell RNA sequencing.

Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19

This study identifies PS receptors, including AXL, as facilitators of SARS-CoV-2 infection by enhancing virus entry into human lung cells, suggesting AXL as a therapeutic target for COVID-19.

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

Phase separation of RNA-binding protein promotes polymerase engagement and transcription

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

This study identifies FASN as a therapeutic target in KRAS-mutant lung cancer by showing its role in lipid metabolism and ferroptosis induction.

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.

The Progenetix oncogenomic resource in 2021

The paper updates the Progenetix resource with expanded cancer copy number variation data, improved quality, and enhanced data access tools.

Improved microbial community characterization of 16S rRNA via metagenome hybridization capture enrichment

The paper develops 16S rRNA sequence capture baits to improve microbial community characterization by balancing the advantages of amplicon and shotgun metagenomic methods.

Chemical composition, antimicrobial and antioxidant activities of essential oils from the receptacle of sunflower (Helianthus annuus L.)

This study evaluates the chemical composition, antimicrobial, and antioxidant activities of essential oils from sunflower receptacles, showing their potential as natural preservatives and medicines.

Nrf2 Activator PB125 as a Potential Therapeutic Agent Against COVID-19

The paper investigates how PB125, an Nrf2 activator, reduces ACE2 and TMPRSS2 expression and cytokine production in cells, potentially mitigating COVID-19 severity.

Not all MDAs should be created equal-determinants of MDA impact and designing MDAs towards malaria elimination

This study develops a spatially explicit model of malaria transmission to show how MDA impact depends on implementation logistics, human mobility, and spatial transmission patterns.

Integrated phylogenomic analyses reveal recurrent ancestral large-scale duplication events in mosses

The paper identifies four polyploidy events in the evolutionary history of Physcomitrella patens, including two ancient duplications and one associated with Bryopsida diversification.

Midgut Transcriptome Analysis of Clostera anachoreta Treated with Cry1Ac Toxin

This study identifies genes and pathways in Clostera anachoreta larvae exposed to Cry1Ac toxin, suggesting potential targets for pest control.

Clinical Significance of C4d Deposition in Renal Tissues from Patients with Primary Sj&oumlgren's Syndrome--A Preliminary Study

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

Alternative splicing and translation play important roles in parallel with transcriptional regulation during rice hypoxic germination

This study identifies alternative splicing and translation initiation as key post-transcriptional mechanisms in rice hypoxic germination, revealing novel pathways and proteins involved in stress response.