G. Han

Structures of PSI-FCPI from Thalassiosira pseudonana in high light provide convergent evolution and light-adaptive strategies in diatom FCPIs

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

Three pollen QTLs are sufficient to partially break stylar unilateral incompatibility of Solanum pennellii

This study identifies two new pollen UI QTLs in Solanum pennellii and shows that three pui QTLs together can partially break stylar unilateral incompatibility.

Identification and Analysis of SARS-CoV-2 Mutation and Subtype using 2x tiled Primer Set with Oxford Nanopore Technologies Sequencing for Enhanced Variant Detection and Surveillance in Seoul, Korea

The paper uses long-read sequencing with a 2x tiled primer set to identify SARS-CoV-2 mutations and subtypes in Seoul, Korea, showing improved variant detection and genotype-patient characteristic correlation.

Epithelial organoid supports resident memory CD8 T cell differentiation

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

Cooperation between bacteriocytes and endosymbionts drives function and development of symbiotic cells in mussel holobionts

The paper constructs a single-cell expression atlas of gill tissue in deep-sea mussels to study the molecular function and developmental trajectory of bacteriocytes and their interaction with endosymbionts.

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

ME3BP-7 is a novel 3BP formulation that resists serum degradation and kills MCT1-high pancreatic cancer cells with low toxicity in mice.

Quantifying cell viability through organelle ratiometric probing

This paper introduces a fluorescent probe, PCV-1, and an analytical assay called organelle ratiometric probing (ORP) to quantify cell viability at the single-cell level using super-resolution microscopy.

FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

This study shows that FMRP deficiency leads to altered splicing via Mbnl1 auto-splicing and redistribution of MBNL1 isoforms, affecting splicing in multiple RNAs.

Cardiac performance and heat shock response variation related to shell colour morphs in the mudflat snail Batillaria attramentaria

This study compares thermal stress responses and transcriptomic profiles of different shell colour morphs in the snail Batillaria attramentaria, finding that dark morphs exhibit preparative defense strategies and higher cardiac thermal tolerance.

Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer

This study integrates multi-omic and phenotypic data to predict therapeutic response in leukemia and ovarian cancer, identifying biomarker profiles and mechanisms of resistance.

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

The paper uses super-resolution microscopy and a fluorescent probe to analyze lysosome spatial organization relative to mitochondria, revealing changes in distance distribution patterns during autophagy and linking lysosome positioning to mitochondrial health.

Immune microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphoma.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

Wzc and WcaJ mutations in hypervirulent Klebsiella pneumoniae lead to phage resistance at the cost of reduced virulence

This study identifies mutations in wzc and wcaJ genes in hypervirulent Klebsiella pneumoniae that confer phage resistance but reduce virulence.

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

Prevailing role of mucosal immunoglobulins and B cells in teleost skin immune responses to bacterial infection

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

Cell-of-Origin Analysis of Metastatic Gastric Cancer Uncovers the Origin of Inherent Intratumor Heterogeneity and a Fundamental Prognostic Signature

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

iTALK: an R Package to Characterize and Illustrate Intercellular Communication

iTALK characterizes and illustrates intercellular communication in tumor microenvironments using single-cell RNA sequencing data.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

Increased H. pylori stool shedding and EPIYA-D cagA alleles are associated with gastric cancer in an East Asian hospital

The paper assesses H. pylori stool shedding and cagA genotype in gastric cancer patients and non-cancer controls, finding higher stool shedding and association with the East Asian cagA allele.