D. Hao

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNA

The paper identifies Schlafen-11 and -9 as innate immune sensors that recognize intracellular single-stranded DNA containing CGT motifs, leading to cytokine expression and cell death.

Simulation study of Cell Transmembrane Potential and Electroporation Induced by Time-Varying Magnetic Fields

This study simulates transmembrane potential and electroporation caused by time-varying magnetic fields, showing that nanosecond pulses are more effective than sub-microsecond pulses for membrane electroporation.

Fracture healing is delayed in the absence of gasdermin signaling

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

Functionalized extracellular matrix scaffolds loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

iTRAQ-Based Proteomic Profiling of PLC-Mediated Expression of 20E-Induced Protein in Apolygus lucorum (Meyer-Dür)

This study uses iTRAQ proteomics to identify 20E and PLC inhibitor-regulated proteins in Apolygus lucorum, revealing shared and distinct DEPs and their involvement in metabolic and signaling pathways.

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.