M. Dang

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma

This study shows TREM2 promotes phagocytosis in gliomas and is not linked to immunosuppression, suggesting TREM2 activation could enhance immunotherapy for brain tumors.

Immune Contexture of Isocitrate Dehydrogenase stratified Human Gliomas

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

Myricetin allosterically inhibits Dengue NS2B-NS3 protease as studied by NMR and MD simulations

This paper identifies Myricetin as an allosteric inhibitor of Dengue NS2B-NS3 protease, showing it disrupts the active conformation and locks the inactive one through binding to new and existing allosteric sites.

No Correlation Between Pollen Fertility and Viability: Differential Measures of Male Gametophytic Fitness in Cannabis sativa L.

The paper measures pollen fertility and viability in Cannabis sativa, finding no significant correlation between the two, suggesting both metrics are needed to assess male gametophytic fitness.

Immune microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphoma.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

Structural basis of anti-SARS-CoV-2 activity of HCQ: specific binding to N protein to disrupt its interaction with nucleic acids and LLPS

This paper identifies HCQ's specific binding to SARS-CoV-2 N protein to inhibit nucleic acid interaction and LLPS, showing its potential as an anti-SARS-CoV-2 drug effective against variants.

SATB2 induction of a neural crest mesenchyme-like program drives invasion and drug resistance in melanoma

This study shows SATB2 drives melanoma invasion and drug resistance by inducing a neural crest mesenchyme-like transcriptional program in zebrafish and human models.

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.