Author

P. Brennan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 3 Bioengineering· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 5 Assay:proteomics· 4 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

E. O. Long· 3 shared J. Lu· 3 shared M. J. W. Sim· 3 shared P. D. Sun· 3 shared S. Knapp· 2 shared A. Chaikuad· 1 shared A. E. Spira· 1 shared A. Goldstein· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersImmunology

E. O. Long

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3

M. J. W. Sim, K.-i. Hanada, Z. S. Stotz, Z. Yu, J. Lu, P. Brennan, M. Quastel, G. Gillespie, E. O. Long, J. C. Yang, P. D. Sun

The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.

bioRxiv · Feb 1, 2024Immunology

Nondestructive Spatial Lipidomics for Glioma Classification

D. A. Martella, L. A. Rose, N. Rouatbi, C. Gu, V. Caprettini, M. Jensen, C. Hagemann, A. Serio, K. Al-Jamal, M. Parsons, M. Bergholt, P. Brennan, A. Zaritski, C. Chiappini

This study develops a nondestructive method using nanoneedles and mass spectrometry to perform spatial lipidomics on brain tissues, enabling accurate glioma classification without damaging the tissue.

bioRxiv · Mar 9, 2023Bioengineering

Innate receptors with high specificity for HLA class I-peptide complexes

M. J. W. Sim, P. Brennan, K. L. Wahl, J. Lu, S. Rajagopalan, P. D. Sun, E. O. Long

The paper identifies peptide-specific binding of KIR receptors to HLA class I complexes, revealing differences in specificity between inhibitory and activating KIRs.

bioRxiv · Feb 6, 2023Immunology

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

D. P. O'Brien, H. B. Jones, F. Guenther, E. J. Murphy, K. S. England, M. Anderson, P. Brennan, J. B. Davis, A. Pinto-Fernandez, A. P. Turnbull, B. M. Kessler

This study investigates how a benzosulfonamide compound inhibits USP30, a mitochondrial deubiquitylating enzyme, using biochemical and structural methods to reveal its binding mechanism and selectivity.

bioRxiv · Sep 13, 2022Biochemistry

T cells discriminate between groups C1 and C2 HLA-C

M. J. W. Sim, Z. Stotz, J. Lu, P. Brennan, E. O. Long, P. D. Sun

This study shows that T cells can distinguish between C1 and C2 HLA-C groups due to differences in peptide presentation and TCR affinity.

bioRxiv · Nov 11, 2021Immunology

An international report on bacterial communities in esophageal squamous cell carcinoma

J. Nomburg, S. Bullman, D. Nasrollahzadeh, E. A. Collisson, B. Abedi-Ardekani, L. O. Akoko, J. R. Atkins, G. C. Buckle, S. Gopal, N. Hu, B. Kaimila, M. Khoshnia, R. Malekzadeh, D. Menya, B. T. Mmbaga, , K. Van Loon

This study identifies bacterial communities associated with esophageal squamous cell carcinoma (ESCC) tumors and finds similar enrichment of oral bacteria in both saliva and tumor microbiomes of ESCC patients.

bioRxiv · Sep 29, 2021Microbiology

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

A. Sinjab, G. Han, W. Treekitkarnmongkol, K. Kobayashi, P. Brennan, M. Dang, D. Hao, R. Wang, E. Dai, H. Dejima, J. Zhang, E. Bogatenkova, B. Sanchez-Espiridion, K. Chang, D. R. Little, , H. Kadara

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Structural insights into interaction mechanisms of alternative piperazine-urea YEATS domain binders in MLLT1

X. Ni, D. Heidenreich, T. Christott, J. Bennett, M. Moustakim, P. Brennan, O. Fedorov, S. Knapp, A. Chaikuad

The paper characterizes piperazine-urea derivatives as acetyl/acyl-lysine mimetics for MLLT1 and reveals distinct interaction mechanisms through crystal structures.

bioRxiv · Nov 9, 2019Biochemistry

Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces

P. Brennan, D. Bowkett, R. Talon, C. Tallant, C. Schofield, F. Von Delft, S. Knapp, G. Bruton

The paper identifies potential small molecule binding sites at domain-domain interfaces of epigenetic proteins using computational and experimental methods.

bioRxiv · Mar 16, 2018Biochemistry