Physical basis of lumen shape and stability in a simple epithelium
C. G. Vasquez, V. T. Vachharajani, C. Garzon-Coral, A. R. Dunn
This study investigates the physical mechanisms of lumen formation in MDCK cell spheroids, finding that lumen shape and stability arise from geometrical factors and apico-basal polarity rather than hydrostatic pressure or actomyosin cytoskeleton.
bioRxiv · Apr 7, 2020 · PreprintCell Biology