Author

C. Stashko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

V. M. Weaver· 3 shared F. Kai· 2 shared G. Timblin· 2 shared J. J. Northey· 2 shared M.-K. Hayward· 2 shared V. Weaver· 2 shared A. Combes· 1 shared A. Dillin· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

V. M. Weaver

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

D. T. McSwiggen, H. Liu, R. Tan, S. Agramunt Puig, L. B. Akella, R. Berman, M. Bretan, H. Chen, X. Darzacq, K. Ford, R. Godbey, E. Gonzalez, A. Hanuka, A. Heckert, J. J. Ho, , H. Beck

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

bioRxiv · Jan 5, 2023Cell Biology

Myeloid mechano-metabolic programming restricts anti-tumor immunity

K. Tharp, K. Kersten, O. Maller, G. Timblin, C. Stashko, F. Canale, M.-K. Hayward, I. Berestjuk, J. ten Hoeve-Scott, B. Samad, R. Geiger, A. Combes, V. Weaver

This study shows that fibrotic tumor microenvironments impair anti-tumor immunity through myeloid cell-driven metabolic changes that hinder CD8+ T cell function.

bioRxiv · Jul 14, 2022 · PreprintCancer Biology

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

J. J. Northey, Y. Yui, M.-K. Hayward, C. Stashko, F. Kai, J. K. Mouw, D. Thakar, J. N. Lakins, A. J. Ironside, S. Samson, R. A. Mukhtar, E. S. Hwang, V. M. Weaver

The paper shows that stiff extracellular matrix and integrin mechanosignaling increase mammary stem-progenitor cells, promoting breast cancer risk and progression through RANK signaling.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

Microenvironmental engineering improves the self-organization of patterned microvascular networks

K. A. Cabral, V. Srivastava, M. C. Coyle, C. Stashko, V. Weaver, Z. J. Gartner

This study shows that engineering the microenvironment with fibrillar matrices and removing a serum component improves the self-organization of patterned endothelial cells into perfusable microvascular networks.

bioRxiv · Apr 4, 2022 · PreprintBioengineering

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

F. Kai, G. Ou, R. W. Tourdot, C. Stashko, G. Gaietta, M. F. Swift, N. Volkmann, A. F. Long, Y. Han, H. H. Huang, J. J. Northey, A. M. Leidal, V. Viasnoff, D. M. Bryant, W. Guo, , V. M. Weaver

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

bioRxiv · Jul 14, 2021 · PreprintCell Biology

Adhesion-mediated mechanosignaling forces mitohormesis

K. M. Tharp, R. Higuchi-Sanabria, G. Timblin, B. Ford, C. Garzon-Coral, C. Schneider, J. M. Muncie, C. Stashko, J. Daniele, A. S. Moore, P. Frankino, S. Manoli, H. Shao, A. L. Richards, K.-H. Chen, , V. M. Weaver

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

bioRxiv · Mar 6, 2020Cell Biology