Cell BiologybioRxiv
Adhesion-mediated mechanosignaling forces mitohormesis
K. M. Tharp, R. Higuchi-Sanabria, G. Timblin…·V. M. Weaver
The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.
DOI 10.1016/j.cmet.2021.04.017