C. Georgescu

A NOVEL UNBIASED SEED-BASED RNAi SCREEN IDENTIFIES SMALL RNAs THAT INHIBIT ANDROGEN SIGNALING AND PROSTATE CANCER CELL GROWTH

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

DIETARY PROTECTION AGAINST THE VISUAL AND MOTOR DEFICITS INDUCED BY EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

This study shows that a ketogenic diet reduces visual and motor deficits in mice with experimental autoimmune encephalomyelitis by decreasing inflammation and preserving myelination.

Four novel, immortal cell lines derived from embryos of Xenopus tropicalis

The paper describes the development of four immortal cell lines from Xenopus tropicalis embryos and characterizes their karyotype and transcriptome.

The NOTCH3 Downstream Target HEYL Regulates Human Airway Epithelial Club Cell Differentiation

This study identifies HEYL as a downstream target of NOTCH3 that regulates human airway epithelial club cell differentiation through in vitro and in vivo analyses.

Detecting potential reference list manipulation within a citation network

The paper identifies potential reference list manipulation by analyzing citation patterns and using the Gini Index to detect skew, estimating 16% of authors may engage in it.

SEED-MEDIATED RNA INTERFERENCE OF ANDROGEN SIGNALING AND SURVIVAL NETWORKS INDUCES CELL DEATH IN PROSTATE CANCER CELLS

The paper shows that specific small RNAs inhibit androgen signaling and induce cell death in prostate cancer cells by targeting AR-coregulatory genes through 3-UTR complementarity.

E proteins orchestrate dynamic transcriptional cascades to suppress ILC2 differentiation

This study identifies E proteins as suppressors of ILC2 differentiation by repressing a transcriptional network through upregulation of repressor genes.

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.

A Tumor Suppressor-Regulated Cell Cycle Derived Gene Signature Is Prognostic Of Recurrence Risk In Prostate Cancer

The paper develops a gene signature based on Tmeff2-regulated cell cycle genes that predicts recurrence risk in prostate cancer and outperforms existing prognostic markers.