Author

C. Giannangelo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Assay:perturbation screen· 1

Frequent Co-Authors

D. J. Creek· 3 shared G. Siddiqui· 3 shared S. A. Charman· 2 shared A. De Paoli· 1 shared A. E. De Paoli· 1 shared A. K. Schuh· 1 shared B. M. Anderson· 1 shared C. A. MacRaild· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

D. J. Creek

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

R. C. Edgar, G. Siddiqui, T. R. Malcolm, S. Duffy, M. Chowdhury, J. Marfurt, G. Wirjanata, R. Noviyanti, K. Daware, M. Dans, C. D. Suraweera, N. A. Counihan, R. N. Price, S. Whittlin, V. M. Avery, , S. McGowan

This paper identifies MMV1557817 as a dual aminopeptidase inhibitor effective against multiple Plasmodium species and highlights its potential as a multi-target antimalarial drug.

bioRxiv · Oct 1, 2023Microbiology

Peroxide antimalarial drugs target redox homeostasis in Plasmodium falciparum infected red blood cells

G. Siddiqui, C. Giannangelo, A. E. De Paoli, A. K. Schuh, K. Heimsch, D. Anderson, T. G. Brown, C. A. MacRaild, J. Wu, X. Wang, Y. Dong, J. L. Vennerstrom, K. Becker, D. J. Creek

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.

bioRxiv · Sep 10, 2021Pharmacology & Toxicology

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

C. Giannangelo, G. Siddiqui, A. De Paoli, B. M. Anderson, L. E. Edgington-Mitchell, S. A. Charman, D. J. Creek

This paper shows ozonide antimalarials disrupt Plasmodium falciparum haemoglobin digestion, leading to parasite death and stress responses.

PLOS Pathogens · Jun 26, 2020Peer-reviewedMicrobiology