Author

C. Iserman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Boppana· 1 shared A. Gladfelter· 1 shared A. Kamada· 1 shared A. Levin· 1 shared C. A. Roden· 1 shared C. Theesfeld· 1 shared C. Y. Park· 1 shared D. Vigolo· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Boppana

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2 papers

Recent·Most cited

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

Y. Shen, F. S. Ruggeri, D. Vigolo, A. Kamada, S. Qamar, A. Levin, C. Iserman, S. Alberti, P. St George-Hyslop, T. Knowles

The paper shows that protein condensates undergo a liquid-to-solid transition under mechanical shear, revealing hydrogen bonding as a key factor.

Nature Nanotechnology · Jul 13, 2020Peer-reviewedBiophysics

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

C. Iserman, C. A. Roden, M. Boerneke, R. Sealfon, G. McLaughlin, I. Jungreis, C. Y. Park, A. Boppana, E. Fritch, Y. Hou, C. Theesfeld, O. Troyanskaya, R. S. G. Baric, T. P. Sheahan, K. Weeks, A. Gladfelter

This study shows SARS-CoV-2 N-protein forms liquid-liquid phase separation with specific viral RNA sequences, which is temperature-sensitive and can be modulated by small molecules, offering potential for antiviral drug development.

bioRxiv · Jun 11, 2020 · PreprintBiochemistry