Author

G. McLaughlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Organism:yeast· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Gladfelter· 3 shared A. S. Gladfelter· 2 shared T. Gerbich· 2 shared A. Boppana· 1 shared A. Ghanbari Niaki· 1 shared A. Jalihal· 1 shared B. L. Woods· 1 shared B. M. Stormo· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

A. Gladfelter

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Biomolecular condensates in fungi are tuned to function at specific temperatures

B. M. Stormo, G. McLaughlin, L. Frederick, A. Jalihal, S. Cole, I. Seim, F. Dietrich, A. S. Gladfelter

The paper shows that temperature affects the material properties of Whi3 condensates in fungi, which are optimized by sequence changes for specific climates.

bioRxiv · Nov 27, 2023Cell Biology

RNA-specific condensation promotes auto-regulation of polyQ RNA-binding protein Whi3

T. Gerbich, E. Langdon, G. McLaughlin, B. Stormo, B. Yu, M. Roper, A. Gladfelter

The paper shows that Whi3, an RNA-binding protein in Ashbya gossypii, auto-regulates its own transcripts through RNA-specific condensation, affecting nuclear cycling and gene transcription.

bioRxiv · Apr 25, 2021 · PreprintCell Biology

Biophysical properties governing septin assembly

B. L. Woods, I. L. Seim, J. Liu, G. McLaughlin, K. S. Cannon, A. S. Gladfelter

This study shows septin filaments are isodesmic polymers, and regulatory proteins modulate their biophysical properties to form different structures in yeast.

bioRxiv · Mar 22, 2021 · PreprintCell Biology

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

C. Iserman, C. A. Roden, M. Boerneke, R. Sealfon, G. McLaughlin, I. Jungreis, C. Y. Park, A. Boppana, E. Fritch, Y. Hou, C. Theesfeld, O. Troyanskaya, R. S. G. Baric, T. P. Sheahan, K. Weeks, A. Gladfelter

This study shows SARS-CoV-2 N-protein forms liquid-liquid phase separation with specific viral RNA sequences, which is temperature-sensitive and can be modulated by small molecules, offering potential for antiviral drug development.

bioRxiv · Jun 11, 2020 · PreprintBiochemistry

mRNA structure determines specificity of a polyQ-driven phase separation

E. M. Langdon, Y. Qiu, A. Ghanbari Niaki, G. McLaughlin, C. Weidmann, T. Gerbich, J. A. Smith, J. M. Crutchley, C. M. Termini, K. M. Weeks, S. Myong, A. Gladfelter

The paper shows that mRNA secondary structures determine RNA-RNA interactions that influence phase separation and compartment identity.

bioRxiv · Mar 7, 2018Cell Biology