A. Gladfelter

RNA-specific condensation promotes auto-regulation of polyQ RNA-binding protein Whi3

The paper shows that Whi3, an RNA-binding protein in Ashbya gossypii, auto-regulates its own transcripts through RNA-specific condensation, affecting nuclear cycling and gene transcription.

A gene duplication of a septin provides a developmentally-regulated filament length control mechanism

The paper identifies a gene duplication in Ashbya gossypii that generates two septin proteins with distinct biophysical properties and developmental regulation.

Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging

This paper uses a polymer model to show that spatial patterning of LLPS-promoting and solubilizing elements in SARS-CoV-2 RNA supports genome packaging, compaction, and cyclization without requiring a single packaging signal.

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

This study shows SARS-CoV-2 N-protein forms liquid-liquid phase separation with specific viral RNA sequences, which is temperature-sensitive and can be modulated by small molecules, offering potential for antiviral drug development.

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.

Phosphoregulation provides functional specificity to biomolecular condensates in the cell cycle and cell polarity

The paper shows that phosphorylation of specific residues on Whi3 regulates distinct functional identities of biomolecular condensates in Ashbya gossypii.

Unconventional cell division cycles from marine-derived yeasts

This study identifies unconventional cell division cycles in marine-derived black yeasts, revealing alternative mechanisms not observed in traditional model yeast systems.

mRNA structure determines specificity of a polyQ-driven phase separation

The paper shows that mRNA secondary structures determine RNA-RNA interactions that influence phase separation and compartment identity.

Control of septin filament flexibility and bundling

This study investigates how septin filament properties are regulated by rod composition and nucleotide availability, showing their impact on filament flexibility, bundling, and cell morphogenesis.