Author

C. J. Sutherland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:plant (other)· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. Patel· 2 shared D. A. Baker· 2 shared F. Mohring· 2 shared M. N. Hart· 2 shared R. Henrici· 2 shared R. W. Moon· 2 shared A. D. Cook· 1 shared A. J. Roberts· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

A. Patel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt ubiquitin hydrolysis

C. Smith, R. Henrici, M. Karpiyevich, M. R. Ansbro, J. Hoshizaki, G. J. van der Heden van Noort, D. B. Ascher, C. J. Sutherland, M. C. S. Lee, K. Artavanis-Tsakonas

The paper investigates mutations in Plasmodium UBP-1 linked to drug resistance and shows how these mutations affect ubiquitin hydrolysis and parasite fitness.

bioRxiv · Sep 15, 2022 · PreprintMicrobiology

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission

T. Liu, F. Shilliday, A. D. Cook, R. Tewari, C. J. Sutherland, A. J. Roberts, C. A. Moores

This study investigates the molecular mechanism of Plasmodium kinesin-8B, showing its role in male gamete development and parasite transmission through ATP-dependent microtubule interactions and structural adaptations.

bioRxiv · Feb 11, 2022Biochemistry

MOSQUITO TRANSMISSION AND HUMAN HEPATOCYTE INFECTIONS WITH Plasmodium ovale curtisi AND P. ovale wallikeri

M. Kristan, S. G. Thorburn, J. Hafalla, C. J. Sutherland, M. C. Oguike

This paper describes a protocol for transmitting Plasmodium ovale curtisi and P. ovale wallikeri to mosquitoes and infecting human hepatocytes, using sensitive DNA detection methods.

Transactions of The Royal Society of Tropical Medicine and Hygiene · Jun 4, 2019Peer-reviewedMicrobiology

Modification of an atypical clathrin-independent AP-2 adaptin complex of Plasmodium falciparum reduces susceptibility to artemisinin

R. C. Henrici, R. L. Edwards, M. Zoltner, D. A. van Schalkwyk, M. N. Hart, F. Mohring, R. W. Moon, S. D. Nofal, A. Patel, C. Flueck, D. A. Baker, A. Odom John, M. C. Field, C. J. Sutherland

This study shows that modifying the AP-2 adaptin complex in Plasmodium falciparum reduces susceptibility to artemisinin, suggesting alternative mechanisms of drug resistance beyond pfkelch13 mutations.

bioRxiv · Apr 30, 2019 · PreprintMicrobiology

Rapid and iterative genome editing in the zoonotic malaria parasite Plasmodium knowlesi: New tools for P. vivax research

F. Mohring, M. N. Hart, T. A. Rawlinson, R. Henrici, J. A. Charleston, E. Diez Benavente, A. Patel, J. Hall, N. Almond, S. Campino, T. G. Clark, C. J. Sutherland, D. A. Baker, S. J. Draper, R. W. Moon

This study develops CRISPR-Cas9 genome editing in Plasmodium knowlesi to generate a transgenic line expressing P. vivax Duffy binding protein, showing its role in host cell tropism and vaccine potential.

bioRxiv · Mar 28, 2019Microbiology